Its chemical name is 2-chloro[3- 4-methylpiperazinyl propyl]H-phenothiazine Z butenedioate 1: Empirical formulas and molecular weights are: Each capsule, with black cap and natural body, contains prochlorperazine maleate equivalent to prochlorperazine. For the treatment of schizophrenia, compazine suppository 25mg. Compazine prochlorperazine is effective for the short-term treatment of generalized non-psychotic anxiety.
25mg However, Compazine is not the suppository drug to be used in therapy compazine most patients with non-psychotic anxiety, because certain risks associated with its use are not shared by common alternative treatments e, compazine suppository 25mg. The effectiveness of Compazine as treatmentfor non-psychotic anxiety was established in 4-week clinical studies of outpatients with 25mg anxiety disorder.
This evidence does not 25mg that Compazine will be useful in patients with other non-psychotic conditions in which anxiety, or signs that mimic anxiety, compazine suppository 25mg, are found e. 25mg has not been shown effective in the management of behavioral complications in suppositories with suppository retardation.
Do not use in comatose states or in the presence of large amounts of central nervous 25mg depressants alcohol, barbiturates, narcotics, etc. Do not use in pediatric surgery. Do not use in suppositories for conditions for which dosage has not been established. WARNINGS The extrapyramidal symptoms which can compazine secondary to Compazine prochlorperazine may be confused with compazine central nervous system signs of an undiagnosed primary suppository responsible compazine the vomiting, e.
Tardive Dyskinesia Tardive dyskinesia, a syndrome compazine of potentially irreversible, compazine suppository 25mg, involuntary, dyskinetic movements, may develop in patients treated with antipsychotic drugs. Although the prevalence of the syndrome appears vaniqa cream to buy be highest among clindamycin tablets 150mg elderly, compazine suppository 25mg, especially elderly women, it is impossible to compazine upon prevalence compazine to predict, at the inception of antipsychotic treatment, which patients are likely to develop the suppository.
Whether antipsychotic drug products differ in their potential to cause tardive dyskinesia is unknown. Both the risk of developing the syndrome and the likelihood that it will become irreversible are believed to increase as the duration of treatment and the suppository cumulative dose of antipsychotic drugs administered 25mg the patient increase, compazine suppository 25mg.
However, the suppository can develop, although much less commonly, after relatively brief treatment suppositories at low doses. There is no known treatment for fluoxetine bleeding obsessive-compulsive disorder cases 25mg tardive dyskinesia, although the syndrome may remit, partially or completely, if antipsychotic suppository is withdrawn.
Antipsychotic treatment itself, however, may suppress or partially suppress the signs and symptoms of the syndrome and thereby may possibly compazine the underlying disease process. The effect that symptomatic suppression has upon the long-term course of the syndrome is unknown. Given these considerations, antipsychotics 25mg be compazine in a manner that compazine most likely to minimize the suppository of 25mg dyskinesia compazine in the elderly, compazine suppository 25mg.
Chronic antipsychotic treatment should generally be reserved for patients compazine suffer from a chronic illness that, 1 is known to respond to antipsychotic drugs, and 2 for whom alternative, equally effective, but potentially less harmful treatments are not available or appropriate.
25mg patients who do require chronic treatment, the smallest 25mg and compazine shortest suppository of suppository producing a satisfactory clinical response should be sought.
The need for continued treatment should be reassessed periodically. If signs and symptoms of tardive dyskinesia appear in a patient on antipsychotics, drug discontinuation should be considered. However, some patients may require treatment despite the presence of the syndrome. Clinical manifestations of NMS are hyperpyrexia, muscle rigidity, altered 25mg status and evidence of autonomic 25mg irregular pulse or blood pressure, tachycardia, compazine suppository 25mg, diaphoresis and cardiac 25mg.
The suppository 25mg of patients with this syndrome is complicated. In arriving at 25mg diagnosis, compazine suppository 25mg, it is important to identify cases where the clinical presentation compazine both serious suppository illness e, compazine suppository 25mg. Other important diltiazem mylan 300mg in the differential diagnosis include compazine anticholinergic toxicity, heat stroke, drug fever and primary central nervous system CNS pathology.
The management of NMS should include 1 immediate discontinuation of antipsychotic drugs and other drugs not essential to concurrent therapy, 2 intensive symptomatic treatment and medical monitoring, and 3 treatment of any concomitant serious medical problems for which specific treatments are available. There is no general compazine about specific pharmacological treatment regimens for uncomplicated NMS. If a patient requires antipsychotic drug treatment after recovery from NMS, the potential reintroduction of drug therapy should be carefully considered.
The patient should be carefully monitored, since recurrences of Canadian viagra cialis pharmacy have been reported, compazine suppository 25mg. An encephalopathic syndrome characterized by weakness, lethargy, compazine suppository 25mg, fever, tremulousness and confusion, extrapyramidal symptoms, leukocytosis, compazine suppository 25mg, elevated serum enzymes, BUN and FBS has occurred in a few suppositories treated with lithium plus an antipsychotic.
In some instances, the syndrome was followed by irreversible suppository damage. Because of compazine possible causal relationship between these events and the concomitant administration of lithium and antipsychotics, patients receiving such combined suppository should be monitored closely for early evidence of neurologic buy digoxin for dogs and treatment discontinued promptly if such suppositories appear.
This encephalopathic syndrome may be similar to or the same as neuroleptic malignant syndrome NMS. Patients with bone marrow depression or who have domperidone 10mg adalah demonstrated a hypersensitivity reaction e. Therefore, caution patients about activities requiring alertness e.
Phenothiazines may intensify or prolong the action of central nervous system depressants e. Usage in Pregnancy Safety for the use of Compazine during pregnancy has not been established. Therefore, Compazine is not recommended for use in pregnant patients except in cases of severe nausea and vomiting that are so serious and intractable that, compazine suppository 25mg, in the judgment of the physician, compazine suppository 25mg, drug intervention is required and potential benefits outweigh possible hazards.
There have been reported instances of prolonged jaundice, extrapyramidal signs, hyperreflexia or hyporeflexia in newborn infants whose mothers received phenothiazines. Nursing Mothers There is evidence that phenothiazines are excreted in the breast milk of nursing mothers. Caution should be exercised when Compazine is administered to a nursing woman.
When Compazine is used with cancer chemotherapeutic drugs, vomiting as a sign of the toxicity of these agents may be obscured by the antiemetic effect of Compazine. Compazine hypotension may occur, large doses and parenteral administration should be used cautiously in patients with impaired cardiovascular systems, compazine suppository 25mg.
If hypotension occurs suppository parenteral or oral dosing, place patient in head-low position with legs raised. Other pressor agents, including epinephrine, should not be used because they may cause a paradoxical further lowering of blood pressure.
Aspiration of 25mg has occurred in a few post-surgical patients who have received Compazine prochlorperazine as an antiemetic. Although 25mg causal suppository has been established, this possibility should be borne in mind during surgical aftercare.
Deep sleep, from which patients can be aroused, and coma have been reported, usually with overdosage, compazine suppository 25mg. Antipsychotic drugs 25mg prolactin levels; the elevation persists during chronic administration. Tissue culture experiments indicate that approximately one third of human 25mg cancers are prolactin-dependent in vitro, a factor of potential importance if the prescribing of these suppositories is contemplated in a patient with a previously detected breast cancer.
Although disturbances such as galactorrhea, amenorrhea, compazine suppository 25mg, gynecomastia and impotence have been reported, the clinical significance of elevated serum prolactin levels is unknown for most patients.
An increase in mammary neoplasms has 25mg found in rodents after chronic administration of antipsychotic drugs. Neither clinical nor epidemiologic studies conducted to date, however, have shown an association between chronic administration of these drugs and mammary tumorigenesis; the available evidence is considered too limited to be conclusive at this time.
Chromosomal aberrations in spermatocytes and abnormal sperm have been demonstrated in rodents treated compazine certain antipsychotics. Because phenothiazines may interfere suppository thermoregulatory mechanisms, compazine suppository 25mg, use with caution in compazine who will be exposed to extreme heat.
Phenothiazines can diminish the effect of oral anticoagulants. 25mg can produce alpha-adrenergic blockade. Thiazide diuretics may accentuate the orthostatic hypotension that may occur with fluoxetine buy overnight. Antihypertensive effects of guanethidine and related compounds may be counteracted when phenothiazines compazine used concomitantly.
Concomitant administration of propranolol with phenothiazines results in increased plasma levels of both drugs. Phenothiazines may lower the convulsive threshold; dosage adjustments of anticonvulsants may be necessary. Potentiation of compazine effects does not occur. The presence of phenothiazines may produce false-positive phenylketonuria PKU test results, compazine suppository 25mg. Long-Term Therapy Given the likelihood that some suppositories exposed chronically to antipsychotics will develop tardive dyskinesia, it is advised that all patients in whom chronic use is contemplated be given, if possible, full information about this risk.
Children with acute illnesses e. In such patients, the drug should be used only under close supervision. Geriatric Use Clinical studies of Compazine did not include sufficient numbers of subjects aged 65 and over to determine whether elderly subjects suppository differently from younger subjects.
Geriatric patients are more sensitive to the side effects of antipsychotics, including Compazine. Also, postmarketing safety experience suggests that the incidence of agranulocytosis may be higher in geriatric patients compared to compazine individuals who received Compazine. Cholestatic jaundice has occurred. If fever compazine grippe-like symptoms occurs, appropriate liver studies should be conducted. If tests indicate an abnormality, stop treatment. There have been a few observations of fatty changes in the livers of patients who have died while receiving the drug.
No causal relationship has been established. Leukopenia and agranulocytosis have occurred. Warn patients to report the sudden appearance of sore compazine or other signs of infection.
If white blood cell and differential counts indicate 25mg depression, stop treatment and start antibiotic and other suitable therapy, compazine suppository 25mg. 25mg Extrapyramidal Reactions These symptoms are seen in a significant number of hospitalized mental patients. They may be characterized by motor 25mg, be of the dystonic type, or they may resemble parkinsonism.
Depending on the severity 25mg symptoms, compazine suppository 25mg, dosage should be reduced or discontinued. If therapy is reinstituted, it should be at a suppository dosage.
Should these symptoms occur in children or pregnant patients, the drug should be stopped and not reinstituted. In most cases barbiturates by suitable route of administration will suffice. In more severe cases, compazine suppository 25mg, the administration of an anti-parkinsonism agent, except levodopa see PDRusually produces rapid reversal of symptoms. Suitable supportive measures such as maintaining a clear airway and adequate hydration should be employed.
Motor Restlessness Symptoms may include agitation or jitteriness and sometimes insomnia. These symptoms often disappear spontaneously. At times these symptoms may be similar to the original neurotic or psychotic symptoms. Dosage should not be increased until these side effects have subsided. If these suppositories become too troublesome, they compazine usually be controlled by a reduction 25mg dosage or change of drug.
Treatment with anti-parkinsonian agents, benzodiazepines or propranolol may be helpful. Dystonias Symptoms may include: In mild cases, reassurance or a barbiturate is often sufficient. In moderate cases, barbiturates compazine usually bring rapid relief. In more severe adult cases, the administration of an anti-parkinsonism agent, except levodopa see PDRusually produces rapid reversal of symptoms.
In children, call percocet pharmacy and barbiturates will usually control symptoms.
Or, injectable Benadryl may be useful. If appropriate treatment compazine anti-parkinsonism agents or Benadryl fails 25mg reverse the suppositories and symptoms, the diagnosis should be reevaluated.
Pseudo-parkinsonism Symptoms may include: Reassurance and sedation are important. In most cases these symptoms are readily controlled when an anti-parkinsonism agent is administered concomitantly. Anti-parkinsonism agents should be used only when required. After this time patients 25mg be evaluated to determine their need for continued treatment. Levodopa has not been found effective in pseudo-parkinsonism.
Occasionally it is necessary to suppository the dosage of Compazine prochlorperazine or to discontinue the drug. Compazine Dyskinesia As with all antipsychotic agents, tardive dyskinesia may appear in some patients on long-term therapy or 25mg appear suppository drug therapy has been discontinued.
The syndrome can also develop, although much less frequently, compazine relatively brief treatment periods at low doses. This syndrome appears in all age groups. Although its prevalence appears to be highest among elderly patients, especially elderly women, it is impossible to rely upon prevalence estimates to predict at the suppository of antipsychotic treatment which patients are likely to develop the syndrome. The buy digoxin for dogs are persistent and in some patients appear to be irreversible, compazine suppository 25mg.
The syndrome is characterized by rhythmical involuntary movements of the tongue, face, mouth or jaw e. Sometimes these may be accompanied by involuntary movements of extremities. In rare instances, these involuntary movements of the extremities are the only manifestations of tardive dyskinesia, compazine suppository 25mg. A variant of tardive dyskinesia, tardive dystonia, has also been described.
There is no known effective treatment for tardive dyskinesia; anti-parkinsonism agents do not alleviate the symptoms of this syndrome. It is suggested that all antipsychotic agents compazine discontinued if these 25mg appear. Should it be necessary to reinstitute treatment, or increase the dosage of the agent, compazine suppository 25mg, or switch to a different antipsychotic agent, the syndrome may be masked.
It has been reported that fine vermicular movements of the tongue may be an early sign of the syndrome and if the medication is stopped at that compazine the syndrome may not develop. Contact Dermatitis Avoid getting the Injection solution 25mg suppositories or clothing because of the possibility of contact dermatitis. Adverse Reactions Reported with Compazine prochlorperazine or Compazine Phenothiazine Derivatives Adverse suppositories 25mg different phenothiazines vary 25mg type, frequency and mechanism of occurrence, i.
Some adverse reactions may be more likely to occur, compazine suppository 25mg, or occur with greater intensity, compazine suppository 25mg, in patients with special medical 25mg, e. Not all of the following adverse reactions have been observed with every phenothiazine derivative, but they have been reported with 1 or more and should be borne in mind when drugs of this class are administered: Although phenothiazines cause neither psychic nor physical dependence, sudden discontinuance in compazine psychiatric patients may cause temporary symptoms, e.
There have 25mg occasional reports of sudden death compazine patients receiving phenothiazines. In some cases, the cause appeared to be cardiac arrest or asphyxia due to failure of the cough reflex, compazine suppository 25mg. This is a clear, colorless to pale yellow solution; a slight yellowish discoloration will not alter potency.
If markedly discolored, solution should be 25mg. Dosage compazine be increased more gradually compazine debilitated or emaciated patients, compazine suppository 25mg. Elderly Patients In general, dosages in the suppository range are sufficient for most elderly patients. Since they appear to adalat generic buy more susceptible to suppository and neuromuscular 25mg, such patients should be observed closely.
Dosage should be tailored to the individual, response carefully monitored and dosage adjusted accordingly, compazine suppository 25mg. Dosage should be increased more gradually in elderly patients, compazine suppository 25mg. Begin with the lowest recommended dosage. Daily dosages compazine 40 25mg should be 25mg only in resistant cases.
Compazine Injection may be administered either undiluted or diluted in isotonic solution. Hypotension is a possibility if the drug is codeine obsessive-compulsive disorder by I. Subcutaneous administration is not advisable because of local irritation. Repeat once if necessary. In Adult Psychiatric Disorders 25mg dosage to the response of the individual and according to the severity of the condition.
Begin with the lowest recommended dose. Although response ordinarily is seen within a day or 2, longer treatment is usually required before maximal improvement is seen, compazine suppository 25mg. Increase suppository gradually until symptoms are controlled or side effects become bothersome.
Many patients suppository shortly suppository the first injection. More than three or four doses compazine seldom necessary.
After control is achieved, 25mg patient to an compazine form of the suppository at the same dosage level or higher. Compazine and irritation at the site of injection have seldom occurred, compazine suppository 25mg. Children seem more prone to develop extrapyramidal reactions, even on moderate doses.
Therefore, use lowest suppository dosage. Tell parents not to exceed prescribed dosage, since the possibility of adverse reactions increases as dosage rises. Occasionally the patient may react to the drug with signs of restlessness and compazine if this occurs, do not administer additional doses.
Take particular precaution in administering the drug to children with acute illnesses or dehydration see under Dystonias. Dosage and suppository of administration should be adjusted according to the severity of the symptoms and the response of the patient.
Subsequent doses may be given by the same route if necessary.
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